Challenging TB Worldwide

Challenge TB is the flagship global mechanism for implementing USAID’s TB strategy as well as contributing to TB/HIV activities under the U.S. President’s Emergency Plan for AIDS Relief (PEPFAR). USAID Bureau for Global Health is building and expanding upon previous successful TB control programs which began in 2000. Challenge TB collaborates with other national and international initiatives in providing global leadership and support for national TB control efforts.

Tuberculosis Facts and Figures (2013):

    An estimated 9 million people were newly infected with TB

    360,000 people with TB/HIV died

    An estimated 550,000 children acquired TB

    80,000 children died from TB

    An estimated 480,000 people developed multidrug-resistant TB (MDR-TB)

    An estimated 210,000 people died from MDR-TB

    Of the estimated 9 million new TB cases only 5.7 million were actually diagnosed (64%).

concept circle

Challenge TB Strategies & Principles

The Challenge TB partners operate using a framework which has four strategies:

    Engage stakeholders, including national TB programs, new partners and individuals, and especially youth.

    Empower key decision-makers, people affected by TB, and marginalized and vulnerable populations.

    Evaluate interventions, measure quality, develop evidence, and implement best practices.

    Expand on the provider and service range, and remove barriers to access.

In addition, there are four principles to which Challenge TB partners are committed: quality-focused deliverables and technical assistance; locally owned and generated innovations, research and solutions; innovative approaches, technologies, tools and thinkers; and a patient-centered focus throughout our work.

indonesia patient

Objectives & Intervention Areas

Challenge TB has three objectives, each with several focus areas for interventions:

    Objective 1: Improved access to high-quality patient-centered TB, DR-TB & TB/HIV services

    By improving the enabling environment

    By ensuring a comprehensive, high quality diagnostic network

    By strengthening patient-centered care and treatment.

    Objective 2: Prevent transmission and disease progression

    By targeted screening for active TB

    By implementing infection control measures

    By managing latent TB infection.

    Objective 3: Strength​en​ TB service delivery platforms

    By enhancing political commitment & leadership

    By strengthening drug & commodity management systems

    By ensuring quality data, surveillance and monitoring & evaluation

    By supporting human resource development

    By building comprehensive partnerships & informed community engagement.

child zimbabwe

What does Challenge TB do?

Challenge TB contributes to the WHO End TB Strategy targets:

Vision: A world free of TB

Goal: To end the global TB epidemic

By 2025: A 75% reduction in TB deaths (compared with 2015) and less than 50 cases per 100,000 population.

Global Fund:

Challenge TB assists countries with the full Global Fund life cycle, from epi-analysis and national strategic plans to concept notes and full implementation.


Challenge TB is a cost-effective and efficient mechanism with a particular emphasis on reaching out to vulnerable communities. It assists countries to move towards universal access through a patient-centered approach that identifies and addresses the needs of all patients including women and children.

genexpert testing

Who is implementing Challenge TB?

Challenge TB is led by KNCV Tuberculosis Foundation, who also led USAID’s previous TB control projects: TB CARE I (2010-2015), TB CAP (2005-2010) and TBCTA (2000-2005).

Challenge TB is implemented by a unique coalition of nine international organizations in TB control

Led and managed by:

KNCV Tuberculosis Foundation


Where Does Challenge TB Work?

Challenge TB currently works in 22 countries in Eastern Europe, Central Asia, East Asia and Africa:

    Eastern Europe


    Central Asia

    Afghanistan, Kyrgyzstan, Kyrgyzstan and Kyrgyzstan

    East Asia

    Bangladesh, Burma, Cambodia, India, Indonesia and Vietnam


    Botswana, DR Congo, East Africa Region, Ethiopia, Malawi, Mozambique, Namibia, Nigeria, South Sudan, Tanzania and Zimbabwe

See the countries page for more details on each country.

More Information