Along side Challenge TB's country projects we are also undertaking six global projects. These projects are mainly focussed on research and are multi country/multi year in nature.
Six Challenge TB Global projects
1. Bedaquiline Introduction
3. UN Special Envoy for Tuberculosis
4. Catastrophic Costs
6. Global Fund Hub
The Bedaquiline (BDQ) core coordination project is supporting the introduction of BDQ in Challenge TB countries.
The generic BDQ implementation plan for countries identifies five steps, which also are applicable to introduction of Delamanid and other new drugs:
Challenge TB will support the rapid introduction of new drugs and regimens using a two pronged approach. Firstly by supporting a clinical center of excellence to start treating eligible patients with regimens that contain the new drugs in combination with adequate companion drugs. Secondly, in collaboration with local partners Challenge TB will support regulatory processes, systems and capacity building in preparation of programmatic use of the new drugs.
The Stigma Project aims to develop valid, feasible and efficient methods to measure TB stigma within the community, patient and health worker populations.
UN Special Envoy for Tuberculosis
The goal of the UN Special Envoy (UNSE) for Tuberculosis, Dr. Eric Goosby, is to promote and garner high level support for the dissemination and implementation of the global End TB Strategy and its targets for TB prevention, care and control.
One of the targets of the End TB Strategy is that no TB patient nor their household should face catastrophic costs due to TB, and this target should be achieved by 2020. To monitor progress towards this target, countries will need to measure the occurrence of catastrophic costs as part of the package of investigations required to better describe local and national TB epidemiology, health seeking, and health and social care systems bottlenecks.
This project is field testing a generic protocol and instrument for national TB patient costs surveys to identify patient and health system predictors and the reasons for catastrophic costs in order to guide policies on cost mitigation. In addition, the project aims to determine the baseline and periodically measure the percentage of TB patients treated in the NTP network (and their households) in the country who incur catastrophic (direct and indirect) costs.
This project is a randomized, pragmatic, open-label trial to evaluate the effectiveness of three months of high dose Rifapentine and Isoniazid (3HP) administered as a once-weekly dose (12 weekly doses) against a regular six month IPT course; the study also compares the effectiveness (pragmatic trial) of one course of 3HP to a pulsed annual repeat course of 3HP.
Global Fund Hub
A key strategic objective of Challenge TB is to support timely and successful implementation of Global Fund (GF) grants within the 21 Challenge TB countries. The approach taken to support GF grant implementation at the country level varies depending on need, but a common theme consisting of collaboration, information sharing, leveraging of resources and technical support is applied across the board.
The primary role of this project is to ensure that Challenge TB contributes to successful implementation of GF grants in the countries it operates. This will be done through building on previous experiences to coordinate technical assistance and make it even more efficient, as well as actively monitoring GF grant performance and offering direct support to identify bottlenecks and local solutions to improve performance.