With more than 480,000 cases of multi-drug resistant TB every year and the conventional treatment being long, toxic, expensive, and having very low levels of treatment success, the need for new drugs and regimens is beyond question.
USAID’s Challenge TB project is driving the introduction of new drugs and regimens for the treatment of drug-resistant TB. These new regimens are bringing hope to thousands, some of whom were all out of other options.
With Challenge TB support, all our countries have developed a policy framework, trained staff, expanded diagnostic capacity, and ensured that drugs and budgets have put in place for nationwide access for all eligible patients. In addition, Challenge TB has supported the development and implementation of active pharmacovigilance systems and procedures to manage adverse events (aDSM), both of which are necessary for the safe use of the new and repurposed medicines.
Individualized regimens containing Bedaquiline are now available in all Challenge TB supported countries, Delamanid is in 14 countries, and the shorter regimen is in 20 countries with the final 2 due to start shortly.
Ethiopia began rolling out the ‘Shorter Treatment Regimen’ for the treatment of drug-resistant TB in April 2018.
Alem Aweke and Takele Abera from Addis Ababa, and Alem Ferede from Gonder were the first three patients to be enrolled.
The new regimen cuts the treatment duration from two years to only 9 months, the number of pills that need to be taken is reduced by almost half, and treatment is much cheaper than the original 20-24 month regimen. Patients only receive injections for the first four months of treatment and perhaps most importantly, the costs incurred by patients having to make daily visits to health facilities, will be significantly reduced.
One of the first three patients, Alem Aweke, said: “I have been told that I do not need to take the TB drugs for 2 years and if I take my drugs properly I will be cured in 9 months! What more do I need? I am so happy.”
The Challenge TB project in Ethiopia is assisting with the start-up of the Shorter Treatment Regimen at treatment initiation centers. This support will lead to better patient management and support, and as the treatment duration is significantly shorter, patients will be better able to adhere to their treatment and finally be cured.
The app (which is freely available for anyone to use) was tested in several health facilities and used to identify children with TB symptoms who are then taken aside for further testing. If you want to know the results, you can read the full story here.
Dhaka, Bangladesh has become the latest city to sign up to the Zero TB Cities Initiative. The initiative will combine a public awareness campaign with TB screening, in order to help find many more of the “missing” TB cases.
A recent TB prevalence revealed very high rates of TB in the urban areas of Bangladesh, and Dhaka is estimated to have more than 150,000 missed TB cases every year.
As Dhaka is the fourth most densely-populated city in the world, controlling this airborne disease is critical to ending the TB epidemic in the country.
At the launch event, the US Ambassador to Bangladesh Marcia Bernicat praised the initiative, she said: “This is significant because Bangladesh has the seventh highest prevalence rate of TB in the world by bringing Dhaka into this initiative, we will be better able to prevent, identify and treat TB and help save lives.”
The initiative in Dhaka was launched with the support of USAID/Challenge TB.
In loving memory of Dr Bashir Popoola Zakariyya who died on the 17th of October 2017, aged 39.
You were the Regional Senior Manager Nasarawa for the Challenge TB Project, full of life and focussed on getting the best results. You always ensured there were no gaps in services, even when we were short staffed.
You are not here with us, but we have you in our hearts. At the start of every new working day, we picture you coming into the office and doing your rounds, greeting everyone and giving a smile as you passed by.
Your name is still mentioned as though you were still at your desk or somewhere in the office.
You are sorely missed, your impact was great, and your name will be mentioned a million times over.
Dr. Bashir Popoola Zakariyya, may your gentle soul rest in peace.
The need for tools to measure stigma has been voiced before, only to be lost in the louder din of voices calling for new technologies, new medicines, and the rush to meet targets, deadlines, benchmarks and count up ‘cases’ that were ‘cured’. Past efforts to measure TB stigma have been stymied by doctrinal differences, internecine debates over definitions, and a pedantry that excluded many important stakeholders. Measuring TB stigma is not an elite project, but it does present some real technical challenges.
Read the full IJTBLD supplement on TB Stigma here.
“Wellness On Wheels” the mobile truck equipped with digital X-ray and GeneXpert was launched today in Ogun State – Nigeria. The Challenge TB-financed truck and equipment, will offer free TB testing services in communities and provide rapid testing for persons with presumed TB, meaning people with TB disease can be placed on treatment as quickly as possible.
Nigeria has the 4th highest burden of TB in the world and the highest in Africa. With 600,000 cases annually and only 100,500 detected in 2016, around 83% of the cases were missed and are in the community infecting those around them. The new truck will take diagnostic facilities directly to the people, where it is hoped it will help to find these missing cases and begin to turn the tide of the disease in the country.
You can now read about our successes and impact on the Challenge TB’s Medium page. New stories will be posted regularly, so follow us to stay up to date with how our work is helping those most in need across 23 countries.
Our latest story highlights how the introduction of new drugs and regimens in Kyrgyzstan is making a difference in the lives of four-year-old Ilias and his two-year-old sister Sumaya, who were diagnosed with DR-TB in February 2017.
Our second annual report gives details on our activities in each country, documents our successes, and reflects on the challenges we faced over the year. Challenge TB implements projects at the country, regional and international/global level with the majority of the program’s work being done through country-specific projects. As of September 30, 2016, there were a total of 21 country projects implemented in Year 2 under Challenge TB. In this report we also cover the Call to Action in India; finding the missing cases; and the childhood TB. You can download the full report here.
The only laboratory capable of cuture and drug susceptibility testing in Botswana was the National TB Reference Laboratory (NTRL), which until recently was mostly out of commission as the TB containment facility had not been functional for almost two years.
With technical support from Challenge TB, the Ministry of Health installed a new ventilation system and Challenge TB also financially supported the refurbishment of the NTRL containment facility.
The renovation was successfully completed in August 2016 and the laboratory became fully operational and resumed receiving and testing patient samples on the 1st September 2016. The laboratory was officially reopened by the US Ambassador to Botswana Mr Earl Miller and the Permanent Secretary of the Ministry of Health, Ms Shenaaz El-Halabi.